Wayne A Cabral Selected Research

Collagen Type I (Type I Collagen)

1/2020	Substitution of murine type I collagen A1 3-hydroxylation site alters matrix structure but does not recapitulate osteogenesis imperfecta bone dysplasia.
1/2017	Cyclophilin B Deficiency Causes Abnormal Dentin Collagen Matrix.
4/2016	Cyclophilin-B Modulates Collagen Cross-linking by Differentially Affecting Lysine Hydroxylation in the Helical and Telopeptidyl Domains of Tendon Type I Collagen.
1/2016	Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta.
6/2014	Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta.
12/2012	Effects of tissue hydration on nanoscale structural morphology and mechanics of individual Type I collagen fibrils in the Brtl mouse model of Osteogenesis Imperfecta.
11/2012	Absence of FKBP10 in recessive type XI osteogenesis imperfecta leads to diminished collagen cross-linking and reduced collagen deposition in extracellular matrix.
6/2011	New perspectives on osteogenesis imperfecta.
2/2010	Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding.
1/2010	Prolyl 3-hydroxylase 1 and CRTAP are mutually stabilizing in the endoplasmic reticulum collagen prolyl 3-hydroxylation complex.

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Wayne A Cabral Research Topics

Disease

24	Osteogenesis Imperfecta (Lobstein Disease) 01/2020 - 03/2003
3	Developmental Bone Diseases (Bone Dysplasia) 01/2020 - 01/2010
3	Ehlers-Danlos Syndrome (Syndrome, Ehlers-Danlos) 04/2007 - 05/2005
2	Progeria (Hutchinson Gilford Syndrome) 01/2021 - 01/2020
1	Melorheostosis 01/2020
1	Type IX Osteogenesis Imperfecta 01/2017
1	Alzheimer Disease (Alzheimer's Disease) 11/2015
1	Neurodegenerative Diseases (Neurodegenerative Disease) 11/2015
1	Type V Osteogenesis Imperfecta 02/2015
1	type 6 Osteogenesis imperfecta 06/2014
1	Dehydration (Water Stress) 12/2012
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2010
1	Connective Tissue Diseases (Connective Tissue Disease) 07/2008
1	Bone Diseases (Bone Disease) 03/2007
1	Osteoporosis 12/2006
1	Autosomal Dominant Type VII Ehlers-Danlos Syndrome 03/2006

Drug/Important Bio-Agent (IBA)

20	Collagen Type I (Type I Collagen)IBA 01/2020 - 03/2003
13	CollagenIBA 01/2020 - 03/2003
10	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2006
4	2-oxoglutarate 3-dioxygenase prolineIBA 01/2020 - 03/2007
3	cyclophilin BIBA 04/2016 - 02/2010
2	InterferonsIBA 01/2020 - 02/2015
2	Procollagen Type IIBA 01/2019 - 06/2011
2	CalciumIBA 01/2017 - 01/2016
2	IntegrinsIBA 07/2008 - 03/2007
2	Glycine (Aminoacetic Acid)FDA LinkGeneric 04/2007 - 03/2003
1	DNA (Deoxyribonucleic Acid)IBA 01/2021
1	Adenine FDA LinkGeneric 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	Lamin Type A (Lamin A)IBA 01/2021
1	Zoledronic Acid (Zometa)FDA Link 01/2020
1	lonafarnib (SCH 66336)IBA 01/2020
1	Pravastatin (Pravachol)FDA LinkGeneric 01/2020
1	Lysine (L-Lysine)FDA Link 04/2016
1	CationsIBA 01/2016
1	Presenilin-1IBA 11/2015
1	Prion ProteinsIBA 11/2015
1	Flavin-Adenine Dinucleotide (FAD)IBA 11/2015
1	PrionsIBA 11/2015
1	Proline (L-Proline)FDA Link 11/2015
1	Cyclophilins (Cyclophilin)IBA 11/2015
1	pigment epithelium-derived factorIBA 06/2014
1	Biological ProductsIBA 12/2012
1	HSP47 Heat-Shock Proteins (Heat Shock Protein 47)IBA 06/2011
1	Diphosphonates (Bisphosphonates)IBA 06/2011
1	Human Growth Hormone (Saizen)FDA LinkGeneric 06/2011
1	Mixed Function Oxygenases (Monooxygenases)IBA 02/2010
1	alpha2 Subunit Collagen Type IIBA 01/2010
1	Cysteine (L-Cysteine)FDA Link 04/2007
1	Amino Acids FDA Link 04/2007
1	Proteoglycans (Proteoglycan)IBA 03/2007

Therapy/Procedure

1	Therapeutics 01/2020
1	Operative Surgical Procedures 06/2011